Lozenges / Troches (Hard, Soft, or Chewable)

Lozenges / TrochesLozenges (a.k.a. troches) are used for patients who cannot swallow solid oral dosage forms as well as for medications designed to be released slowly to yield a constant level of drug in the oral cavity or to bathe the throat tissues in a solution of the drug. Drugs often incorporated into lozenges include analgesics, anesthetics, antimicrobials, antiseptics, antitussives, aromatics, astringents, corticosteroids, decongestants, and demulcents. However, this is by no means an exhaustive list as many other drugs may lend themselves to delivery by a lozenge. As well, both single and multi-ingredient lozenges can be compounded, depending on the particular patient's needs.

How do we compound your lozenges?

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Choosing a Formulation

Depending on the drug being compounded, the pharmacist will choose a specific base to use in the lozenge. Their selection will take into consideration such things as the flavor of the base, whether the base is stable, compatible with the drug(s) being compounded, stable during storage, will melt or dissolve in the mouth, and most importantly, will not bind or otherwise interfere with the release or absorption of the drug. Depending on the drug(s) and the dosage to be included in the lozenge, the pharmacist will determine the size of lozenge to be used and calculate the amounts of base to use.

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Measuring the Ingredients

Next, the drug and the base will be weighed out accurately on a prescription weigh scale. As well, flavors and preservatives will be weighed.


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Preparing the Drug and The Molds

The drug is ground into as fine a powder as possible using a mortar and pestle. The molds may be lubricated if necessary.


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Base Preparation

Depending on the base, it may be ground up into smaller pieces first, and then melted to a specific temperature on a hot plate.

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Mixing and Pouring

The drug and any other ingredients are often mixed directly into the base and then mixed using a stir rod or a magnetic stirring setup. Once sufficiently mixed, the melt is poured into the mold such that the molds are uniformly filled.

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Cooling and Finishing

Depending on the base and drug, the lozenges will require varying times at room temperature to solidify, sometimes followed by refrigeration to completely solidify them.

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The lozenges are most often left in the molds so that they may be popped out one-by-one as the patient requires a dose. The entire mold + lozenges are usually slipped into a cardboard sleeve for dispensing where they are labeled appropriately for the patient they were compounded for. Lot number and expiry date are noted and any special storage instructions are included.